Strong PSMA Expression by a Pituitary Macroadenoma on PSMA PET/CT.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 41428620.
- Also identified by DOI 10.1097/RLU.0000000000006279.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
An 81-year-old man was found to have an elevated PSA, prompting a prostate biopsy that revealed Gleason grade 7 (3+4) prostate cancer. For staging purposes, an 18 F-DCFPyL PSMA PET/CT was performed, which demonstrated focal uptake in the pituitary region corresponding to a suprasellar mass. Subsequent pituitary MRI confirmed the presence of a pituitary macroadenoma. The expanding global use of PSMA PET has increasingly revealed PSMA ligand uptake in a variety of non-prostatic benign and malignant conditions, creating false positive results. Our case highlights that pituitary macroadenoma may have strong PSMA expression and should be recognized as a potential imaging pitfall.
Medical subject headings
- Pituitary Neoplasms
- Positron Emission Tomography Computed Tomography
- Glutamate Carboxypeptidase II
- Antigens, Surface
- Adenoma
- Gene Expression Regulation, Neoplastic