18 F PSMA Uptake in a Hypogastric Desmoid Tumor.

López-Bermejo García, Fernando; Jiménez Lara, Araceli; Rodríguez Gómez, José Carlos; Gatón Ramírez, Javier; Poblete García, Victor Manuel · Clin Nucl Med · 2026

case_report · Level V

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Abstract

A 68-year-old man with a history of 2 primary tumors (prostate adenocarcinoma and colon adenocarcinoma) underwent 18 F-DCFPyL PET/CT for biochemical recurrence after prostate cancer treatment. A hypogastric nodular lesion with avid PSMA uptake was observed, interpreted as a possible implant. Surgical excision revealed a benign spindle cell proliferation compatible with a desmoid tumor (fibromatosis). This case highlights the potential pitfall of desmoid tumors mimicking malignancy on 18 F-DCFPyL PET/CT, emphasizing the importance of awareness and correlation with clinical and histopathologic findings.

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