Unexpected 18 F-PSMA-1007 Uptake in a Colonic Diverticulum : A Benign Mimicker of Metastatic Prostate Cancer.
case_report · Level V
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- Record sourced from PubMed, PMID 41428836.
- Also identified by DOI 10.1097/RLU.0000000000006179.
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Abstract
A 68-year-old man with rising PSA (0.363 ng/mL) 6 years post-prostatectomy underwent 18 F-PSMA-1007 PET/CT. The scan revealed rib metastasis and an unexpected PSMA-avid focus in the ascending colon. Previous 68 Ga-PSMA and subsequent 18 F-FDG PET both showed no abnormal uptake in the ascending colon area. Colonoscopy confirmed an ascending colon diverticulum. This rare case demonstrates intense 18 F-PSMA-1007 uptake in a colonic diverticulum, likely attributable to PSMA expression by neovascular endothelium or inflammatory cells. Clinicians should consider colonic diverticulum in the differential diagnosis of PSMA-avid colonic lesions to prevent misdiagnosis.
Medical subject headings
- Prostatic Neoplasms
- Diverticulum, Colon
- Oligopeptides