A Causal Relationship Between the Lipidome and Central Nervous System Tumors.

Abstract

The incidence of central nervous system (CNS) tumors is increasing. However, despite advances in treatment, the etiological factors and mechanisms remain poorly understood. Recent studies have increasingly linked the lipidome to the development of CNS tumors. However, the actual association between liposomes and nervous system tumors remains speculative and lacks definitive conclusions. To address this gap, we used a Mendelian randomization approach to systematically evaluate the association between the lipidome and 5 common types of CNS tumors. Our findings revealed a causal association between 16 lipids and glioblastoma, 6 lipids and benign meningiomas, 2 lipids and pituitary tumors and craniopharyngiomas, 3 lipids and benign cranial nerve tumors, and 2 lipids and benign spinal cord tumors. This study represents the first comprehensive examination of the association between lipid groups and common CNS tumors, offering crucial insights for further fundamental research into the etiology and clinical management of these conditions.