Dual-Tracer PET/CT in Erysipelas-like Cutaneous Metastases From Salivary Duct Adenocarcinoma: FAPI Illuminates What FDG Missed.
case_report · Level V
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- Record sourced from PubMed, PMID 41432593.
- Also identified by DOI 10.1097/RLU.0000000000006253.
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Abstract
Cutaneous metastases are rare manifestations of malignancies. We report a case of a 50-year-old man with an atypical presentation of erysipelas-like skin lesions, later found to be cutaneous metastases from an unknown primary. 18 F-FDG PET/CT revealed visceral metastases; however, it failed to demonstrate uptake in the skin lesion, while 68 Ga-FAPI PET/CT additionally showed intense uptake in the skin, including the right parotid gland, which is likely the primary site. IHC findings confirmed a primary salivary duct adenocarcinoma. This case underscores FAPI PET/CT's utility in detecting FDG-negative lesions and identifying occult primaries in atypical presentations, also reflecting the intratumoral heterogeneity of salivary duct carcinomas.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Fluorodeoxyglucose F18
- Skin Neoplasms
- Salivary Gland Neoplasms
- Adenocarcinoma
- Salivary Ducts