Bacteria-responsive DNAgel system for targeted delivery of photothermally enhanced MXene/MoS<sub>2</sub> in the treatment of pyogenic osteomyelitis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41438206.
- Also identified by DOI 10.1016/j.bioactmat.2025.10.023 and PMC identifier 12720349.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Pyogenic osteomyelitis (POM) presents significant clinical challenges due to persistent infections and impaired bone regeneration. Here, we developed a bacteria-responsive MXene/MoS<sub>2</sub> DNAgel (MXMoS<sub>2</sub> DNAgel) with enhanced photothermal antibacterial capabilities to treat POM. By doping molybdenum disulfide (MoS<sub>2</sub>) quantum dots onto MXene nanosheets, the hydrogel exhibited significantly improved near-infrared (NIR) photothermal conversion, facilitating efficient bacterial eradication. The DNA-based hydrogel responded selectively to bacterial DNase, allowing for infection-triggered release of therapeutic components. Furthermore, the MXMoS<sub>2</sub> DNAgel reduced inflammation by modulating macrophage polarization from pro-inflammatory M1 toward anti-inflammatory M2 phenotypes and promoted osteogenic differentiation through activation of the Wnt signaling pathway. Both <i>in vitro</i> and <i>in vivo</i> studies demonstrated excellent antibacterial efficacy, robust bone regeneration, and favorable biocompatibility. Collectively, this multifunctional hydrogel offers a promising therapeutic platform for targeted management and healing of infectious bone diseases.