Modern challenges in infection prevention: encapsulated organisms in the era of novel complement inhibitors.

Al Jurdi, Ayman; Kotton, Camille N; Lafayette, Richard · Kidney Int · 2026

review · Level V

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Abstract

Complement inhibitors are now approved for use in atypical hemolytic uremic syndrome, IgA nephropathy, and C3 glomerulopathy. They are being studied widely in kidney disease, and more indications may soon arise. This review addresses an approach to preventing infectious complications, particularly encapsulated organism infections, and will hopefully serve as guidance for nephrologists utilizing these agents.

Medical subject headings