Impact of Right Cerebellar Theta Burst Stimulation on Post-Stroke Aphasia: A Randomized Controlled Trial.
rct · Level II
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- Record sourced from PubMed, PMID 41485564.
- Also identified by DOI 10.1016/j.apmr.2025.12.012.
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Abstract
To compare the effects of intermittent Theta Burst Stimulation (iTBS), continuous TBS (cTBS), and sham stimulation of the right cerebellum on language function, cognitive function, and quality of life in post-stroke aphasia (PSA) patients. Randomized controlled trial. Department of Rehabilitation, The First Affiliated Hospital of Jinan University, Guangzhou, China. Sixty PSA patients were randomly assigned to three groups: iTBS (n=20), cTBS (n=20), and sham stimulation (n=20). Each patient received personalized speech training right after stimulation, five days a week, for two weeks. The iTBS, cTBS, and sham stimulation were applied to the right cerebellum. Treatment effects were evaluated using the Chinese versions of the Western Aphasia Battery (WAB) for language function, the Non-Language-Based Cognitive Assessment (NLCA) for cognitive function, and the Stroke Aphasia Quality of Life Scale (SAQOL-39g) for quality of life. ANOVA revealed a significant interaction between time and group (P < 0.001). Post-hoc comparisons indicated that the cTBS group outperformed the iTBS and sham groups in language function, cognitive function, and quality of life scores post-treatment (p < 0.05). No significant differences were found between the iTBS and sham groups (p > 0.05). cTBS stimulation of the right cerebellum significantly enhanced language cognitive function and quality of life in patients with aphasia, suggesting it as a promising target for neuromodulation treatment and offering new hope for rehabilitation strategies.