Similar and yet not quite the same: unmasking distinct type I interferon signatures in ANCA vasculitis.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 41485804.
- Also identified by DOI 10.1016/j.kint.2025.10.002.
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Abstract
Antineutrophil cytoplasmic autoantibody-associated vasculitides can be classified by clinical phenotype or antineutrophil cytoplasmic autoantibody specificity, with overlapping yet distinct characteristics. Transcriptomic analyses of kidney biopsies from 2 French antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) cohorts revealed a pronounced type I interferon signature in microscopic polyangiitis (microscopic polyangiitis/myeloperoxidase-AAV) compared with granulomatosis with polyangiitis (granulomatosis with polyangiitis/proteinase 3-AAV). Among biopsies with high interferon scores, 66% were myeloperoxidase-AAV and 28% proteinase 3-AAV. The interferon score was associated with decreased kidney survival. These findings highlight AAV patient heterogeneity and support targeted treatment approaches.
Medical subject headings
- Interferon Type I
- Granulomatosis with Polyangiitis
- Antibodies, Antineutrophil Cytoplasmic
- Kidney
- Microscopic Polyangiitis
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis