Holistic AI in medicine; improved performance and explainability.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41495177.
- Also identified by DOI 10.1038/s41746-025-02298-3 and PMC identifier 12873290.
- Licence recorded as CC BY-NC-ND.
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Abstract
With the increasing interest in deploying Artificial Intelligence in medicine, we previously introduced HAIM (Holistic AI in Medicine), a framework that fuses multimodal data to solve downstream clinical tasks. However, HAIM uses data in a task-agnostic manner and lacks explainability. To address these limitations, we introduce xHAIM (Explainable HAIM), a novel framework leveraging Generative AI to enhance both prediction and explainability through four structured steps: (1) automatically identifying task-relevant patient data across modalities, (2) generating comprehensive patient summaries, (3) using these summaries for improved predictive modeling, and (4) providing clinical explanations by linking predictions to patient-specific medical knowledge. Evaluated on the HAIM-MIMIC-MM dataset, xHAIM improves average AUC from 79.9% to 91.3% across chest pathology and operative tasks. Importantly, xHAIM transforms AI from a black-box predictor into an explainable decision support system, enabling clinicians to trace predictions back to relevant patient data, bridging AI advancements with clinical utility.