Context matters: Causality and global epidemiology of proton pump inhibitor safety.

Okabayashi, Shinji; Kaplan, Gilaad G · PLoS Med · 2026

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Abstract

Proton pump inhibitors revolutionized acid-related disorder therapy, yet widespread overuse has raised concerns about long-term safety. A recent study in PLOS Medicine presents new evidence assessing whether links between their prolonged use and upper gastrointestinal cancer are causal.

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