Benign form of monogenic obesity conferred by the melanocortin 4 receptor.
Where this comes from
- Record sourced from PubMed, PMID 41500196.
- Also identified by DOI 10.1016/j.cmet.2025.12.006.
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Abstract
Mutations that impair the function of the melanocortin 4 receptor (MC4R) cause severe obesity in both heterozygous and homozygous carriers. However, recent findings indicate that individuals with this form of monogenic obesity may be unexpectedly protected against dyslipidemia and cardiovascular diseases.
Medical subject headings
- Obesity
- Receptor, Melanocortin, Type 4