Incidence and Severity of Postacute Sequelae of SARS-CoV-2 Infection in the Omicron Era: A Prospective Cohort Study.

Lin, Dan-Yu; Mischell, Melissa A; Zhang, Xinyu; Mollan, Katie R; Zhang, Ning; Nanyakkara, Dinelka; Keys, Jessica R; Straub, Becky et al. · J Infect Dis · 2026

prospective_cohort · Level II

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Abstract

In a prospective cohort study of 2,960 non-hospitalized adults with acute SARS-CoV-2 infection, older age, female sex, rural residence, high BMI, greater acute infection severity, chronic lung disease, and poorer general health at baseline were associated with higher risk and severity of postacute sequelae. Recent vaccination was associated with lower postacute sequelae risk and severity, while antiviral therapy was not.