Reverse engineering the beat: Assembloid modeling of sympathetic control of the heart.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41512830.
- Also identified by DOI 10.1016/j.stem.2025.12.012.
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Abstract
Liu et al.<sup>1</sup> generate human sympathetic ganglion organoids and assemble them with heart-forming organoids to build functionally connected sympathetic-cardiac organoids in vitro. Their platform captures autonomic development, neuromodulation of heart function, and metabolic injury, opening new opportunities to study human autonomic disorders and cardiometabolic disease.<sup>2</sup>.
Medical subject headings
- Heart
- Organoids
- Sympathetic Nervous System
- Ganglia, Sympathetic