Pineal gland organoids illuminate human melatonin and circadian regulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41512833.
- Also identified by DOI 10.1016/j.stem.2025.12.009.
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Abstract
Human pineal development and neuroendocrine regulation remain incompletely understood at the molecular and functional levels. Kiral et al.<sup>1</sup> establish human pineal gland organoids (hPGOs) that recapitulate pinealocyte maturation, noradrenergic responsiveness, and melatonin synthesis, providing a platform for investigating circadian dysfunction and disease-associated sleep disturbances.
Medical subject headings
- Organoids
- Melatonin
- Pineal Gland
- Circadian Rhythm