When heme is low, copper kills cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 41512845.
- Also identified by DOI 10.1016/j.cell.2025.12.010.
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Abstract
Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respiratory chain to release copper and kill acute myeloid leukemia cells by cuproptosis.
Medical subject headings
- Copper
- Heme
- Leukemia, Myeloid, Acute
- Neoplasms