An organic-inorganic composite bone cement based on oxidized carboxymethyl cellulose/carboxymethyl chitosan hydrogel and magnesium phosphate with excellent antibacterial and antioxidant properties.
basic_science · Level V
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- Record sourced from PubMed, PMID 41518886.
- Also identified by DOI 10.1016/j.jmbbm.2026.107342.
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Abstract
Magnesium phosphate cement (MPC) is promising for bone repair but limited by high curing temperature, rapid setting, and brittleness. This study developed an organic-inorganic composite MPC incorporating CaCl<sub>2</sub>•6H<sub>2</sub>O and oxidized cellulose/carboxymethyl chitosan (OCMC/CMCS) gel to address these issues. The effect of OCMC/CMCS content on composite properties was investigated. The formulation with 5 % OCMC/CMCS (5 %-O) demonstrated optimal performance: lower setting temperature (∼31 °C), prolonged setting time (30.92 ± 0.95 min), adequate compressive strength (11.21 ± 2.34 MPa), improved toughness, injectability (87.64 ± 1.69 %), and enhanced degradation (27.89 ± 0.83 % on day 28). It also exhibited significant antibacterial activity against S. aureus (inhibition rate 82.79 ± 0.68 %) and antioxidant capacity (maximum scavenging rates of 38.64 ± 3.20 % for DPPH and 100 % for ABTS), while maintaining good biocompatibility and osteogenic potential. This composite shows a significant potential for cancellous bone repair.
Medical subject headings
- Chitosan
- Anti-Bacterial Agents
- Bone Cements
- Antioxidants
- Hydrogels
- Phosphates
- Carboxymethylcellulose Sodium
- Magnesium Compounds