Chronically implantable μLED arrays for optogenetic cortical surface stimulation in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41530143.
- Also identified by DOI 10.1038/s41467-025-68191-5 and PMC identifier 12827276.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cortical implants are a proven clinical neurotechnology with the potential to transform our understanding of cognitive processes. These processes rely on complex neuronal networks that are difficult to selectively probe or stimulate. Optogenetics offers cell-type specificity, but achieving the density and coverage required for chronic, high-resolution modulation remains a challenge. We fabricated 100-element μLED arrays (200 μm pixel pitch, 2 × 2 mm<sup>2</sup> footprint) coupled into chronically implantable systems for optogenetic stimulation of the mouse cortex. The μLEDs remain stable for over 300 hours continuous operation time in vivo, allowing for months-long chronic experiments. Simultaneous electrophysiology recordings confirmed robust neuronal responses at low μLED drive currents (< 5 mA), minimising thermal effects. Here we show that our device can be chronically implanted in freely-behaving mice and drive behavioural outcomes from spatiotemporal, patterned, optogenetic stimulation of auditory cortical circuits.
Medical subject headings
- Optogenetics
- Auditory Cortex
- Cerebral Cortex