Maternal phylloquinone intake and early neurodevelopment: implications for prenatal nutrition.
Where this comes from
- Record sourced from PubMed, PMID 41530486.
- Also identified by DOI 10.1038/s41390-025-04756-w.
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Abstract
Vitamin K supports neurodevelopment through sphingolipid regulation critical for myelination and neuronal integrity, anti-inflammatory effects via NF-κB pathway inhibition, and improved maternal glucose metabolism and insulin sensitivity. Current prenatal recommendations of vitamin K (70-90 µg/day), based solely on coagulation needs, may be insufficient for optimal brain development. A target of 140 µg/day warrants consideration in future guidelines. Routine assessment of vitamin K status in prenatal care offers a safe and low-cost opportunity to support neurodevelopment and reduce developmental inequities at the population level.
Medical subject headings
- Neurodevelopment
- Vitamin K 1
- Prenatal Nutritional Physiological Phenomena
- Maternal Nutritional Physiological Phenomena
- Brain