Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety.

Chao, Ariana M; Gilden, Adam; Wadden, Thomas A · PLoS Med · 2026

review · Level V

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Abstract

Glucagon-like peptide-1 (GLP-1)-based medications, such as semaglutide and tirzepatide, have transformed obesity care. However, rising use brings concerns about side effects, long-term outcomes, and unregulated products. Ensuring safe access requires oversight, monitoring, and coordinated clinical care.

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