The Hype and the Hope: Where Do We Stand with Prostate-specific Membrane Antigen-targeted Fluorescence-guided Surgery?

Ottens, Vera A; Chiarelli, Giuseppe; Contieri, Roberto; van Leeuwen, Fijs W B; van der Poel, Henk G · Eur Urol · 2026

review · Level V

Where this comes from

Abstract

Early studies highlight the promise of prostate-specific membrane antigen-targeted fluorescence-guided surgery. Realization of the full potential of this strategy will require ongoing technical refinement and the integration of hybrid-guided approaches, supported by high-quality clinical evidence, to translate feasibility into meaningful oncological benefits.