Assembling unregulated DNA segments bypasses synthesis screening: regulate fragments as select agents.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41540044.
- Also identified by DOI 10.1038/s41467-025-67955-3 and PMC identifier 13057468.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
U.S. select agent regulations ignore easily assembled DNA fragments, making synthesis screening ineffective regardless of accuracy. We acquired unregulated DNA collectively sufficient for a skilled individual to generate 1918 influenza from dozens of providers, demonstrating that fragments must be regulated as select agents.