Electrochemical desulfurative borylation of thiols, disulfides, thioethers and thioacetals.
basic_science · Level V
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- Record sourced from PubMed, PMID 41540045.
- Also identified by DOI 10.1038/s41467-025-67363-7 and PMC identifier 12816636.
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Abstract
Low-valent sulfur-containing compounds are abundant among natural and synthetic products but remain underutilized as starting materials in desulfurative transformations. Herein, we present thiols, disulfides, thioethers, and thioacetals as precursors in a direct desulfurative electrochemical process for the formation of alkylboronic esters, including late-stage functionalization of pharmaceutically relevant scaffolds and natural products. The electrochemical protocol is simple, user-friendly and scalable, successfully producing gram quantities of borylated product.