Elevated tRNA halves in olfactory epithelial cells of patients with schizophrenia.

Gumas, Justin T; Shigematsu, Megumi; Borgmann-Winter, Karin E; Hahn, Chang-Gyu; Kirino, Yohei · J Clin Invest · 2026

basic_science · Level V

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Abstract

Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.

Medical subject headings