Rectal Indomethacin Administration Is Associated with a Lower Prevalence of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in Children: An Observational Cohort Study.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 41544752.
- Also identified by DOI 10.1016/j.jpeds.2026.114990.
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Abstract
Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) rates are higher in children than adults, for whom PEP prophylaxis with rectal indomethacin is standard of care. We analyzed the records of children undergoing endoscopic retrograde cholangiopancreatographies performed during indomethacin unavailability and found the PEP rate was 11.1% when this medication was unavailable vs 3.6% when it was used (P < .001) in age- and complexity-matched groups. Rectal administration of indomethacin appears safe and effective for pediatric PEP prophylaxis.
Medical subject headings
- Cholangiopancreatography, Endoscopic Retrograde
- Pancreatitis
- Indomethacin
- Anti-Inflammatory Agents, Non-Steroidal