Topographical Variation of Iron-Rimmed Lesions in the Multiple Sclerosis Brain and Spinal Cord: A Neuropathological Study.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41549562.
- Also identified by DOI 10.1002/ana.78113 and PMC identifier 12954142.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Paramagnetic-rim lesions are a novel diagnostic marker in multiple sclerosis (MS) and are associated with poor prognosis due to their link with chronic inflammation and disease progression. Analyzing 46 postmortem MS cases, researchers found no iron rims in 67 white matter and 85 grey matter spinal cord lesions, despite most being active. In contrast, iron rims appeared in 20.9% of cortical and 80% of subcortical brain lesions, especially in deeper myelin-rich cortical layers. These findings highlight the regional variability of iron accumulation and have important implications for interpreting iron-rims in MS diagnosis, monitoring, and prognostication. ANN NEUROL 2026;99:730-736.
Medical subject headings
- Multiple Sclerosis
- Iron
- Spinal Cord
- Brain
- White Matter