Beyond Parkinsonism: 18 F-FDOPA Brain PET/MRI for Detection of High-grade Glioma.
case_report · Level V
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- Record sourced from PubMed, PMID 41553742.
- Also identified by DOI 10.1097/RLU.0000000000006337.
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Abstract
A 72-year-old man presented with right-sided rigidity and bradykinesia, but the history and neurological examination were not entirely compatible with degenerative parkinsonism. Initial MRI showed T2/FLAIR hyperintensity within the splenium, attributed to small vessel disease. Subsequent 18 F-FDOPA brain PET/MRI ruled out degenerative parkinsonism, but revealed avid tracer uptake (SUVmax 4.46) in the splenium corresponding to signal abnormality on structural imaging. This unexpected finding prompted contrast-enhanced MRI brain, which identified a peripherally enhancing splenium lesion concerning for neoplasm. Stereotactic biopsy confirmed GFAP-positive, diffuse high-grade glioblastoma, IDH-wildtype, WHO Grade 4, highlighting the role of FDOPA PET in the assessment of primary brain tumors.
Medical subject headings
- Magnetic Resonance Imaging
- Positron-Emission Tomography
- Glioma
- Dihydroxyphenylalanine
- Brain Neoplasms
- Multimodal Imaging
- Parkinsonian Disorders