Missing tissue, missing data: Resolving brain volume loss caused by anti-amyloid therapies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41557594.
- Also identified by DOI 10.1371/journal.pmed.1004880 and PMC identifier 12818629.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Anti-amyloid drugs modestly slow Alzheimer's disease progression, albeit with uncertainty of sustained benefit, particularly as they cause paradoxical acceleration of brain volume changes. Here, we examine explanations for these volume changes and argue for transparent release of clinical trial data.
Medical subject headings
- Alzheimer Disease
- Brain
- Amyloid beta-Peptides