Dexmedetomidine Combined With Propofol in Hip Fracture Surgery and Its Effect on Postoperative Pain and Hemodynamics.

Abstract

This study aims to examine the use of dexmedetomidine (DEX) combined with propofol in hip fracture surgery and its effect on postoperative pain and hemodynamics. One hundred forty patients undergoing hip fracture surgery were divided into a treatment group (receiving DEX combined with propofol anesthesia) and a control group (receiving propofol anesthesia). The Ramsay Sedation Scale was used to evaluate the sedative effect 24 hours postoperatively, while the Visual Analog Scale was used to assess the analgesic effect 24 hours after surgery. The Montreal Cognitive Assessment (MoCA) scale was used to evaluate cognitive function before and 24 hours after surgery. Heart rate (HR) and mean arterial pressure (MAP) were recorded at different stages of anesthesia, and the incidence of postoperative adverse reactions was also recorded. Compared with the control group, at 24 hours postoperatively, patients in the treatment group had higher Ramsay sedation scores and lower Visual Analog Scale scores ( P < 0.05). Before surgery, the MoCA scores of both groups showed no significant difference ( P > 0.05), but the treatment group had higher MoCA scores 24 hours after surgery compared with the control group ( P < 0.05). No difference was observed in HR and MAP levels before anesthesia between the two groups ( P > 0.05), while the treatment group performed lower MAP and HR levels than the control group at skin incision and at the end of surgery ( P < 0.05). In addition, the incidence of postoperative adverse reactions was lower in the treatment group than in the control group ( P < 0.05). DEX combined with propofol for composite anesthesia in hip fracture surgery effectively meets the requirements for surgical anesthesia, maintains hemodynamic stability, and exhibits good postoperative analgesic and sedative effects.