Large-scale spatial profiling of the tumor microenvironment.

Kilgallon, Aaron; Tubelleza, Rafael; Kulasinghe, Arutha · Cell · 2026

basic_science · Level V

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Abstract

Multiplex immunofluorescence proteomics is a powerful method in spatial biology to decipher cell types, states, and architecture in tissues. In this issue of Cell, Valanarasu et al. develop GigaTIME, an expansive population-scale analysis of the tumor immune microenvironment of over 14,000 patients across 24 cancer types, enabling clinical discovery and patient stratification.

Medical subject headings