Construction of Function-Integrated Pressure-Sensitive Adhesives for Their Application in Infected Wound Management.

Abstract

Pressure-sensitive adhesives (PSAs) are core materials for wound care and medical fixation, yet their clinical application is constrained by three key contradictions: high adhesiveness easily causes skin damage during peeling, while low adhesiveness leads to dressing edge lifting and increased infection risk, and traditional PSAs generally lack antibacterial and wound-healing-promoting functions. To address these issues, this study proposes a "function-integrated PSAs" strategy by combining emulsion-polymerized cationic polyacrylate (CPPSA) with tunable adhesion and antibacterial properties and chitosan (CS) for hemostasis and wound regulation. This CPPSA-CS system integrates three core synergistic functions: electrostatically targeting and disrupting bacterial cell membranes for antibacterial protection, optimizing adhesive performance to balance bonding stability and low-damage peeling, and accelerating hemostasis and mitigating inflammatory responses at the wound site to modulate the wound microenvironment. This study overcomes traditional PSAs' limitation of single fixation function through material and functional innovation, providing a new technical approach for multi-dimensional infected wound management with significant clinical translation value.