Rubber-like DNA hydrogel enabled by fast-shrinking-induced entanglement.
biomechanical · Level V
Where this comes from
- Record sourced from PubMed, PMID 41605922.
- Also identified by DOI 10.1038/s41467-026-68363-x and PMC identifier 12905201.
- Licence recorded as CC BY-NC-ND.
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Abstract
Biomass DNA holds immense potential as a sustainable material, but the scalable production of robust DNA materials with sufficient mechanical strength remains an essential challenge. Herein, we report a Fast-Shrinking-Induced Entanglement (FaSIE) process to achieve rubber-like hydrogels solely composed of DNA (stiffness >800 kPa, toughness >5 MJ/m<sup>3</sup>, and stretchability > 1000%). Fast shrinking kinetic restricts the chain relaxation, while the ultra-long chain feature of biomass DNA further suppress chain reptation. This synergistic effect enables substantial enhancement of entanglement density, exceeding the threshold required for high mechanical strength. We highlight the broad applicability of this strategy for high-resolution 3D printing of mechanically robust DNA hydrogels and the fabrication of DNA based soft magnetic robots. This approach paves the way for the large-scale production of resilient hydrogel materials derived from biomass DNA for versatile applications.
Medical subject headings
- DNA
- Hydrogels
- Rubber