Cutaneous Toxicities of Small Molecules in Targeted Cancer Therapy Part II - Approach to Management and Treatment.
review · Level V
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- Record sourced from PubMed, PMID 41621675.
- Also identified by DOI 10.1016/j.jaad.2025.11.106.
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Abstract
With the rapid expansion of small molecule inhibitors (SMIs) in oncology, the incidence and complexity of dermatologic adverse events (dAEs) have significantly risen<sup>1</sup>. While SMIs target essential oncogenic pathways, they frequently result in dermatologic toxicities that can impact patient quality of life and lead to dose reduction, treatment interruption, or discontinuation of life-prolonging therapy<sup>1</sup>. Effective management of these toxicities is critical not only for preserving skin integrity but also for ensuring ongoing oncologic treatment. Part II of this CME discusses guidance on oncodermatologic management for dermatologic toxicities due to SMIs.