Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41623180.
- Also identified by DOI 10.1172/JCI197706 and PMC identifier 12867147.
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Abstract
Preclinical data demonstrating that luspatercept mitigates vaso-occlusive and anemia-related complications in the Townes sickle cell model provide a strong rationale for its evaluation in SCD patients.
Medical subject headings
- Anemia, Sickle Cell
- Recombinant Fusion Proteins
- Activin Receptors, Type II
- Immunoglobulin Fc Fragments