Incidental 18 F-Flortaucipir Uptake in Pituitary Macroadenoma.

Xiong, Min; Liu, Yipei; Luo, Xiaoming; Jiang, Sheng-Nan · Clin Nucl Med · 2026

case_series · Level IV

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Abstract

A 73-year-old woman with over 2 years of progressive memory decline underwent amyloid PET/CT ( 18 F-florbetaben) and tau PET/CT ( 18 F-flortaucipir) imaging for suspected Alzheimer disease (AD). This series of examinations confirmed the diagnosis of AD. Unexpectedly, a pituitary macroadenoma with significant 18 F-flortaucipir uptake was revealed, which might represent another instance of off-target binding.

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