Iodine-avid Adenomyoepithelioma of the Breast: A Rare Incidental Finding.

Merkle, Lennart; Jöhrens, Korinna; Schnabel, Jens; Schönemann, Isabel Yolanda; Zöphel, Klaus · Clin Nucl Med · 2026

case_report · Level V

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Abstract

An 83-year-old woman with follicular thyroid cancer (FTC) presented with elevated thyroglobulin levels 5 years after second ablative radioiodine therapy (RAI). A subsequent 18 F-FDG PET/CT revealed small pulmonary nodules and a lesion of the right breast with pathologically increased FDG-uptake. Unexpectedly, the lesion also showed radioiodine uptake under a performed third RAI and was visually absent after a fourth course of treatment. Histologically after core and excisional biopsy, a benign adenomyoepithelioma was confirmed. This is, to our knowledge, the first reported iodine avide adenomyoepithelioma and highlights a rare diagnostic pitfall.

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