Spondylodiscitis: A False-Positive Pitfall in 68 Ga-PSMA Scintigraphy.

Saber Tanha, Amin; Jafari Zarrin Ghabaei, Farid; Ghorbani, Hamidreza; Elahifard, Haniye; Askari, Emran · Clin Nucl Med · 2026

case_report · Level V

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Abstract

A 65-year-old man with elevated serum prostate-specific antigen (PSA) and obstructive urinary symptoms referred for PRIMARY score assessment via 68 Ga-PSMA scintigraphy. The scan showed increased PSMA uptake in vertebral endplates with CT features of spondylodiscitis, confirmed by clinical history and inflammatory markers. Symmetrical PSMA uptake in the prostate corresponded to primary score 2. This case highlights spondylodiscitis as a false-positive on PSMA imaging and emphasizes the importance of correlating PET/CT findings with clinical and laboratory data to avoid misdiagnosis.

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