Reliability and validity of the Persian version of the arm function in multiple sclerosis questionnaire-short form (AMSQ-SF) for assessing upper limb function in multiple Sclerosis patients.

Abstract

Upper extremity function is crucial for daily living activities. This study aimed to validate the Persian version of the 10-item Arm Function in Multiple Sclerosis Questionnaire-Short Form (AMSQ-SF) in individuals with multiple sclerosis (MS). In this cross-sectional study involving 201 individuals with MS, the AMSQ-SF was evaluated for reliability (test-retest in 50 participants) and construct validity against a battery of established performance-based and patient-reported outcome measures. Spasticity and disability levels were employed to evaluate the questionnaire's ability to differentiate between various subgroups. The Persian AMSQ-SF demonstrated excellent reliability (ICC_(2,1) = 0.94) and internal consistency (α = 0.95). Its strong construct validity was evidenced by correlations in the hypothesized directions with measures of grip strength, quality of life, self-reported function, dexterity, and fatigue. It differentiated patients with and without spasticity and various disability levels (<i>p</i> < 0.001). Clinically useful cutoff scores were established to classify impairment severity (mild ≥16, moderate ≥20, severe ≥26) with high sensitivity (70-81%) and specificity (85-95%). The AMSQ-SF demonstrates strong validity and reliability as a questionnaire for individuals with MS, suitable for use in both research and rehabilitation settings.