18F-FDG PET/CT Findings in a Case of Primary Leptomeningeal Melanomatosis With Diastematomyelia.

Wang, Jingnan; Jin, Xiaona; Shi, Ximin; Jing, Hongli · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Primary leptomeningeal melanomatosis is a rare and aggressive variant of primary central nervous system melanoma. Diagnosis is often challenging due to nonspecific radiologic features. We hereby report the 18F-FDG PET/CT and MRI findings in a case of primary leptomeningeal melanomatosis in a 47-year-old woman with a previously unidentified diastematomyelia. Spinal MRI showed diffuse abnormal signal. 18F-FDG PET/CT showed hypermetabolism most notably in the lumbar and caudal portion of the spinal cord, which was helpful to identify an appropriate site for biopsy.

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