Systematic optimization for the rapid generation of high-quality online adapted proton therapy plans in a commercial treatment planning system.

Nenoff, Lena; Eberhardt, Annabell; Bütof, Rebecca; Fredriksson, Albin; Menkel, Stefan; Gambetta, Virginia; Troost, Esther Gc; Richter, Christian et al. · Radiother Oncol · 2026

basic_science · Level V

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Abstract

Online adaptive proton therapy (OAPT) requires a fast plan optimization. Different optimization parameters of a commercial treatment planning system were investigated for OAPT of locally advanced non-small cell lung-cancer patients. With the selected parameters, clinical-quality plans were optimized within a median time of 4 min, currently deemed acceptable for OAPT.

Medical subject headings