Influence of Chlamydia trachomatis sequence variation on Pgp3 antigenicity.
basic_science · Level V
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- Record sourced from PubMed, PMID 41635928.
- Also identified by DOI 10.1093/infdis/jiag067.
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Abstract
Chlamydia trachomatis (Ct) is a sexually transmitted infection (STI) linked to ectopic pregnancy, infertility, invasive lymphogranuloma venereum (LGV) and the blinding disease trachoma. STI, LGV and trachoma are associated with disease-specific Ct genovars. Serology is an important surveillance tool for estimating exposure, but the impact of genome variation on the antigenicity of Ct proteins is unclear. Two-dimensional antigenicity profiling of Pgp3 antigens representing LGV, STI and trachoma demonstrated differential antigenicity using antigen-specific murine sera, but geometric distances were not considered significant (≤2 fold) for human infection sera. Pgp3 should be considered a single serotype for the purposes of Ct serosurveillance.