Metastasis gets a little help from immune cell mitochondria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41638189.
- Also identified by DOI 10.1016/j.cmet.2026.01.002.
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Abstract
Although a role for mitochondrial transfer has been implicated in metastasis, the mechanisms are unclear. Using mouse metastatic models, Okwan-Duodu and colleagues<sup>1</sup> report that mitochondrial transfer from non-cancer immune cells to cancer cells in the tumor facilitates lymph node metastasis via the cGAS/STING immune evasion pathway involving type I interferon.
Medical subject headings
- Mitochondria