Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise.
rct · Level II
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- Record sourced from PubMed, PMID 41638190.
- Also identified by DOI 10.1016/j.cmet.2026.01.003.
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Abstract
Huang et al.<sup>1</sup> show a J-shaped relationship between vigorous activity and cognitive decline, with maximal benefit ∼1,000-1,300 MET-min/week and harm with excessive exercise. Using UK Biobank data, mechanistic models, and an RCT, they implicate lactate-driven mitochondria-derived vesicles that reach the hippocampus, disrupt synapses, and impair cognition.
Medical subject headings
- Hippocampus
- Mitochondria
- Exercise
- Lactic Acid