Mitochondria at the membrane provide a route to inflammatory cell death.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41638191.
- Also identified by DOI 10.1016/j.cmet.2025.12.019.
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Abstract
In a recent issue of Cell, Wang et al. identify "mitoxyperilysis," a previously unknown lytic cell death pathway where combined innate immune and metabolic stress triggers prolonged mitochondria-plasma membrane contact, causing local oxidative damage and membrane rupture. This mTORC2-regulated process identifies a therapeutic axis for inflammatory diseases and cancer.
Medical subject headings
- Mitochondria
- Inflammation
- Cell Death
- Cell Membrane
- Mitochondrial Membranes