Superior Diagnostic Performance of 99m Tc-FAPI-46 SPECT/CT Versus 18 FDG PET/CT in Detecting Peritoneal Involvement in Mucinous Adenocarcinoma of the Colon.
case_report · Level V
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- Record sourced from PubMed, PMID 41649847.
- Also identified by DOI 10.1097/RLU.0000000000006129.
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Abstract
A 44-year-old man with a history of ulcerative colitis and primary sclerosing cholangitis presented with fecaluria and was found to have rectal and cecal masses, later histologically confirmed as mucinous adenocarcinomas forming rectovesical fistulas. Despite chemotherapy reducing the primary tumor size, elevated serum CEA levels prompted further imaging. An 18 F-FDG PET/CT scan showed no new lesions, but a subsequent 99m Tc-FAPI-46 scintigraphy revealed diffuse peritoneal involvement. During surgery for bowel obstruction, multiple metastatic deposits were identified. This case underscores the superior detection capability of 99m Tc-FAPI-46 SPECT/CT in assessing peritoneal carcinomatosis in colorectal mucinous adenocarcinomas compared with 18 F-FDG PET/CT.
Medical subject headings
- Fluorodeoxyglucose F18
- Adenocarcinoma, Mucinous
- Positron Emission Tomography Computed Tomography
- Peritoneal Neoplasms
- Single Photon Emission Computed Tomography Computed Tomography
- Colonic Neoplasms