A 3D "nichoid" boost for gene-engineered blood stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41650932.
- Also identified by DOI 10.1016/j.stem.2026.01.004.
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Abstract
Midena et al.<sup>1</sup> employ a nanoengineered 3D "nichoid" substrate that mechanically supports CD34<sup>+</sup> hematopoietic stem and progenitor cells (HSPCs) during ex vivo manipulation, reducing culture-associated stress and improving engraftment and polyclonal output after gene editing or lentiviral gene addition. The work spotlights mechanobiology as a manufacturing lever for improving HSPC gene therapies.
Medical subject headings
- Hematopoietic Stem Cells
- Genetic Engineering