A Wireless, Bioresorbable Postoperative Treatment System with Temperature Feedback, Photothermal, and Drug Combination Therapy.

Abstract

Postoperative tumor recurrence remains a significant challenge for the long-term survival of patients. Although synergistic combination therapies involving photothermal therapy and local chemotherapy show considerable promise, critical obstacles remain to clinical translation, such as insufficient temperature monitoring and the difficulty in integrating multiple therapeutic functions. Herein, we report a wireless, bioresorbable postoperative treatment system that integrates temperature feedback, photothermal therapy, and on-demand drug release within a single implantable platform. An asymmetrically interconnected inductive-capacitive (LC) sensor layout enables in situ, real-time temperature monitoring via inductive coupling, while a photothermal patch provides localized heating and controlled drug release. In vitro and in vivo studies, such as the S180 tumor model, demonstrate effective thermal control, stable wireless operation, and enhanced therapeutic efficacy. The device can be implanted after tumor resection surgery to perform its therapeutic functions, and subsequently degrade and be absorbed by the body, providing a multifunctional and clinically compatible strategy for postoperative tumor management.