Global research trends and hotspots of rheumatoid arthritis and mitogen-activated protein kinase-a bibliometrics and visualization analysis.

Abstract

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by synovial hyperplasia and bone erosion, which ultimately leads to joint deformity and disability. The mitogen-activated protein kinase (MAPK) signaling pathway is one of the critical pathways in eukaryotic cells involved in regulating cell mitosis, differentiation, and apoptosis, as well as inflammation and stress responses, and is closely related to the development of RA. Intra-articular cytokines in patients with RA can bind to the corresponding receptors and activate intracellular upstream modulators, which activate the MAPK signaling pathway in a tertiary enzyme-linked manner. This study aimed to explore the research hotspots in the RA and MAPK signaling pathway research and the research focus and intrinsic connections by identifying the number of papers published annually, authors, institutions, keywords, and journals. Through bibliometric analyses, it was found that the number of publications surged from 2000 to 2023, and the number of publications in 2017 exceeded 100 articles/year for the first time; it was also the year with the most significant number of publications, the most considerable number of publications was from China, with 536 articles, and the second-ranked was from the United States, with 384 articles; and the most significant number of authors was from the University of California, USA, with Firestein, Gary s. professor, with 28 articles; the first institution with the most significant number of articles is univ calif san diego from the U.S.A., with 37 articles; in the keyword analysis, the frequency and centrality of the keywords are Nf kappa b (347, 0.04), Activation (231, 0.06), Activated protein kinase (211, 0.08), Gene expression (169, 0.09), Tumor necrosis factor (146, 0.07),The trend is still increasing, suggesting that many publications exploring this area will continue to be reported in the future. This study will help scholars better understand the rheumatoid arthritis and mitogen-activated protein kinase of hotspots in this field and may provide some inspiration for research in this area.