Health Effects Associated With Jet Fuel Exposure: Methods for a Fit-for-Purpose Systematic Review and Systematic Evidence Map.

Abstract

The aim of the study was to present the methods for a fit-for-purpose systematic review designed to assess the health effects of jet fuel exposure in military settings by synthesizing data from epidemiologic, animal toxicological, and mechanistic studies. Methods followed the US Environmental Protection Agency's Integrated Risk Information System and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines with adaptations to meet the needs for this review. A literature search was conducted across scientific databases, gray literature, and expert-identified sources, resulting in the inclusion of 279 relevant references. Results are presented in a systematic evidence map and companion articles. The methods employed ensure transparency in the screening, evaluation, and synthesis of data, establishing a foundation for further research on the health impacts of jet fuel exposure in veterans.