Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases.

Yan, Bingyu; Lee, Jinwoo; Srinivasan, Suhas; Ambriz, Pedro; Shi, Quanming; Dou, Diana R; Davuluri, Srijana; Nandyala, Swarna et al. · J Clin Invest · 2026

basic_science · Level V

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Abstract

Novel autoantibodies target hotspots on the XIST ribonucleoprotein complex in female-biased autoimmune diseases.

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